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Glorieux C, Liu S, Trachootham D, Huang P

Sklan, D., E

In the study of the protective effect of trehalose on oxidative stress damage in sheep epididymal epididymal cells, it was again found that the upregulation of GPX5 plays a key role ( During epididymis transport, spermatozoa are vulnerable to intracellular and extracellular ROS attacks and rely on antioxidant scavengers synthesized by the epididymis for protection

Nat Rev Urol

However, despite these interventions, clinical outcomes remain suboptimal: approximately 30%40% of diabetic foot ulcers fail to heal within 20 weeks of standard care, and the 5-year mortality rate following amputation exceeds 70% ( The impairment of DW healing is a multifactorial, multi-stage pathological process involving hyperglycemia, accumulation of advanced glycation end products (AGEs), oxidative stress, persistent inflammation, impaired angiogenesis, neuropathy, and increased infection risk (Peng et al., 2023) (Table 1)