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Although the majority of desmoplastic/spindle cell melanomas demonstrate S100 protein and/or Sox10 immunoreactivity, partial/or complete loss of expression of these markers such as that observed in malignant peripheral nerve sheath tumors can be found, 20, 21 especially in metastatic cases

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These findings support the idea that GLP-1 medications work best as long term therapies rather than short term interventions

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