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Boyland E, Chasseaud LF: The role of glutathione and glutathione S-transferases in mercapturic acid biosynthesis

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SIRT3 has a comparatively narrower acyl pocket optimized for shorter acyl chains [72], yet it can also de-lactylate specific histone sites (e.g., H3K9 and H4K16) in defined contexts [65] and may act on nuclear substrates under stress, including lactylated proteins such as CCNE2 [73]