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In summary, although IBD is a multifactorial disease in which activation of inflammatory cells is thought to play a key role for its development, the synergism between ROS generation and subsequent GSH depletion induced by TNBS appears to be a key event, at least in this model of acute colitis induced by TNBS+ethanol

Given its importance in the immune system, the NLRP3 inflammasome has drawn significant attention in the study of UC

In recent years, extensive research (Figure 2) has shown that TMAO can activate the inflammasome NOD-like receptor protein 3 (Nlrp3) through different pathways to activate the inflammatory signal pathway, resulting in aggravation of oxidative stress and, in turn, of endothelial dysfunction

Brains were immediately removed and flash-frozen in cold isopentane to preserve RNA

You may also experience some other reactions immediately after the injection is administered