to reduce the risk of major cardiovascular events such as heart attack, stroke, or death in adults with type 2 diabetes with known heart disease
Dose, delivery, and brain absorption matter: Some GLP-1s are better absorbed and have more potential to improve cognitive endpoints than others Combination therapeutics may be required: GLP-1s may need to be paired with lifestyle interventions or complementary neuroprotective agents to produce measurable results in specific disease outcomes
However, more serious issues have also been linked to these drugs, including gallbladder problems, low blood sugar, kidney injury and diabetic retinopathy (damage to the eyes retina)
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Many of the pathophysiology and the signaling pathways involved in this process are also shared by the development of MDS-related TOD