glutathione crohn's disease Gut microbiota-related metabolism is key mechanism for sulforaphane ameliorating ulcerative colitis JPP No 5/2016 article 08

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The largest pool sits in the cytosol, but discrete pools also exist in the nucleus, the endoplasmic reticulum, and the mitochondria the last being disproportionately important because mitochondria are the principal source of the reactive oxygen species generated by normal respiration

Considering an estimated average blood volume of approximately 7%8% of body weight in mice (Diehl et al., 2001), the LD50 dose of 382.28 mg/kg would result in an initial circulating concentration estimated to be in the range of 510 mM

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It is important to note that while many seek off-label uses for athletic performance, FDA-approved treatments specifically target diagnosed medical conditions