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An ongoing phase 3 trial, the SELECT study, will evaluate the cardiovascular benefit of semaglutide beyond blood glucose control, as the study population is composed of individuals who are overweight or obese without diabetes [81]

The antibiotics can also reduce how much magnesium the body absorbs, but this is less of a concern

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These findings support the growing evidence that the established CV benefit of semaglutide is molecule-specific and cannot be generalized to the broader GLP-1 or GLP-1/GIP receptor agonist classes.

Table 2 Reported ghrelin receptor structures