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The mechanistic target of rapamycin (mTOR) functions as a major negative regulator of autophagy
doi:10.1002/jcp.22571, PMID: 21660956 Guha P, Dey A, Sen R, Chatterjee M, Chattopadhyay S, Bandyopadhyay SK (2011) Intracellular GSH depletion triggered mitochondrial Bax translocation to accomplish resveratrol-induced apoptosis in the U937 cell line
But chronic high-dose use may: Overstimulate metabolic pathways Alter methylation balance (since NNMT is tied to methyl donor cycling) Lead to unintended side effects like fatigue, irritability, or hormonal imbalance Stick to researched dosing windows (typically 1020 mg/day for short cycles in animal models) 2
Dihexa is not FDA-approved for any indication and has no published human safety data
PMID: 146 FengHLiuQDengZLiHZhangHSongJet al
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