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Prog Mol Biol Transl Sci 112:3188 De Jonge ME, Huitema ADR, Rodenhuis S, Beijnen JH (2005) Clinical pharmacokinetics of cyclophosphamide

2.1.2 The role of Cys93 in counteracting tissue hypoxia Among the conserved amino acids in hemoglobin, the cysteine at position 93 on the -globin chain (Cys93) plays a key role in the physiological response to low oxygen availability ( During hypoxic stress, hemoglobin undergoes a conformational shift that exposes Cys93, allowing SNO-hemoglobin (SNO-Hb) to form

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10.1186/s12967-022-03629-8 54 LuQ.YangL.XiaoJ