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The approvals are based on robust clinical trial data demonstrating their efficacy and safety with indications typically targeting a specific BMI category (10, 11, 1927)

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Watkins JD, Koumanov F, Gonzalez JT

(8) Excess body weight increases the mechanical load on weight-bearing joints, accelerating cartilage wear and joint degeneration, and contributing to a pro-inflammatory state that further exacerbates joint damage