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No side effects were reported by the participants in Evans' and Fuller's trial (2016[11])

A dedicated phase 2a substudy in people with obesity and metabolic dysfunction-associated steatotic liver disease (MASLD) used MRI to measure liver fat and found that, after 24 weeks, retatrutide reduced relative liver-fat content by about 81% at the 8 mg dose and about 82% at 12 mg, versus essentially no change on placebo

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This biological mechanism facilitates improved glycemic control and appetite regulation, contributing to sustainable weight management outcomes

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