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Avoiding severe calorie restriction: GLP-1 medications should reduce hunger, not encourage near-starvation

On the other hand, NPW treatment depressed the degree of lipid peroxidation, neutrophil infiltration and pro-inflammatory cytokine levels, and elevated antioxidant capacity in conjunction with the downregulation of gastric COX-1 and COX-2 mRNA levels, suggesting that improved gastric damage due to NPW could be eliminating the need for compensatory upregulation of COX enzymes

Some bile acids bind to the G protein-coupled receptor TGR5 and inhibit TNF production by Kupffer cells via the TGR5-cAMP-dependent pathway

Design and activity of specific hypoxia-inducible factor-2alpha (HIF-2alpha) inhibitors for the treatment of clear cell renal cell carcinoma: discovery of clinical candidate (S)-3-((2,2-difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1 H-inden-4-yl)oxy)-5-fluorobenzonitrile (PT2385)

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