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AMIA Annu Symp Proc:927, 2008

f , Uptake of [ 13 C 2 , 15 N]-GSH (5 mM, top) or [ 13 C 4 , 15 N 2 ]-GSSG (0.5 mM, bottom) into mitochondria isolated from HEK-293T SLC25A39 knockout cells expressing a vector control or SLC25A39 cDNA for 10 min

Although CTLA-4 and PD-1 are part of separate pathways, they exert similar inhibitory effects on effector T cell metabolism, including downregulation of AKT phosphorylation, reduced amino acid uptake, and general suppression of metabolic activity

Possibly because NAC does not cross the blood-brain barrier well enough, the patient eventually succumbed to a novel and rapid onset of CNS disease

Costs vary depending on the clinic and number of sessions but typically range from 100 to 300 euros per session