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Fatima Cody Stanford of Massachusetts General Hospital in Boston, who reviewed the findings

376 Similar to systemic IR, brain IR can be defined as failed response to insulin by brain cells, 377,378 primarily due to downregulated insulin receptors, an inability of insulin receptors to bind insulin, or dysfunction of the insulin signaling cascade

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In real-world trials, fewer than 10% of patients discontinued both oral and injectable semaglutide due to side effects