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Minimization of receptor internalization and thus desensitization may contribute to prolonged effects or improved efficacy

The samples were analyzed using the optimized chromatographic method and parameters described in the Section Chromatographic conditions

On a technical note, the majority of preclinical protocols producing beneficial results for TAAR1 agonism, employed intraperitoneal delivery as mode of administration

Taking this trend into consideration and the prevalence of dementia, including AD, the World Health Organization estimates that population aging will lead to a dramatic increase in dementia prevalence

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