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It possesses in vitro balanced GIPR (EC50 = 3 pM) and GLP-1R (EC50 = 5 pM) agonism with relative activity seven times that of GIP to GIPR and five times that of GLP-1 to GLP-1R, respectively ( max at 5.4 nM with a single dose of 1.8 mg (106) and C max at 12 nM at the steady state with a daily dose of 2 mg in patients with T2DM (107)

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Diabetic Ketoacidosis as a Presenting Feature of Acromegaly: When Excess Hormone Meets Hormone Deficiency