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PLoS One 11 (8), e0161208
Clinical features include: Enlargement of the hands, feet, and jaw Paraesthesia in the extremities Amenorrhoea Coarse facial features, including a wide nose and rounded face Hypertension Cardiomegaly (enlargement of the heart) Treatment includes surgical removal of the pituitary tumour , typically via the sphenoid bone (transsphenoidal approach) if the tumour is large enough, or medical management using somatostatin analogues.
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Some individuals report feeling more refreshed and energized after maintaining optimal B12 levels
Although research has examined daily doses ranging from 250 mg to 1,000 mg in healthy adults, the optimal amount may vary depending on individual health status, needs, and underlying conditions
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