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IGF-1R Receptor Binding and Downstream Signalling Both IGF-1 and des-(1-3)IGF-1 bind only to the type 1 IGF receptor in L6 myoblasts, rat vascular smooth-muscle cells, and human lung fibroblasts, with binding potencies in the order des-(1-3)IGF-1 greater than IGF-1 a difference attributed to the lower affinity of des-(1-3)IGF-1 for the competing IGFBP rather than superior intrinsic receptor affinity

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doi: 10.1172/JCI115391 71 NagaiAAoshibaKIshiharaYInanoHSakamotoKYamaguchiEet al