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Translational implications This study offers critical translational insights into the molecular pathogenesis of advanced-stage lipedema, highlighting AKT1 as a central integrator of epigenetic, transcriptomic, and metabolic dysregulation

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Dosage and How to Take Berberine and Alpha Lipoic Acid Berberine is typically taken in divided doses throughout the day due to its relatively short half-life in the body

In high fat diet (HFD) and streptozotocin (STZ)-induced type 2 diabetic mice model and HK-2 cells, after treatment with metformin (200 mg/kg/d) for 24 weeks, some indicators of mitophagy (LC3II, Pink1, Parkin, Atg5) were examined