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However, a multicenter study in 5,485 subjects with cardiovascular disease or diabetes mellitus showed that daily supplementation with folic acid (2.5 mg), vitamin B 12 (1 mg), and vitamin B6 (50 mg) lowered homocysteine concentrations but had no effect on fracture risk compared to placebo (118)

Studies have shown that bevacizumab, as a VEGF inhibitor, has demonstrated neuroprotective effects in several models of TBI (Genovese and Impellizzeri 2022)

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