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Association of pancreatitis with glucagon-like peptide-1 agonist use

It rules out individuals with significant liver disease, uncontrolled thyroid dysfunction, a history of medullary thyroid cancer, or severe gastroparesis, and states that pregnancy and breastfeeding contraindicate semaglutide

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GLP-1 receptors become less sensitive to initial stimulation while maintaining therapeutic effects

This is a pattern seen consistently across many metabolic and weight-related treatments, not just compounds still in the investigational stage