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Treatment with liraglutide injection 1.2 mg and 1.8 mg as add-on to metformin resulted in a significant mean HbA1c reduction relative to placebo add-on to metformin and resulted in a similar mean HbA1c reduction relative to glimepiride 4 mg add-on to metformin (Table 4)

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Upon binding of GLP-1 receptor agonists, GLP-1R activates multiple intracellular cascades, including cAMP/PKA/CREB, MAPK/ERK, and PI3K/AKT

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The average premium for single coverage has grown 24% in the past five years [Figure 1.12]