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The last GSH synthetic process is the one depending on the conversion of the oxidized dimer GSSG to 2 reduced GSH molecules in cells by glutathione reductase (GR), an ubiquitous enzyme of the family of disulfide reductases, in the presence of NADPH and flavin adenine dinucleotide -FAD-

Once delivered into cells, glutathione participates in recycling antioxidants, supporting detox enzyme pathways, and maintaining redox balance

Comparative evaluation of group-based mindfulness-based stress reduction and cognitive behavioral therapy for the treatment and management of chronic pain disorders: protocol for a systematic review and meta-analysis with indirect comparisons

Kamen DL, Aranow C

The WGCNA approach, applied to this set of microarray data, clusters co-regulated genes based on their co-expression pattern and organizes them into modules. An eigengene score is thereafter applied to each module derived from the z-scored log 2-fold change values of the genes consisting the module (module membership)