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286 The landmark SELECT trial has demonstrated the cardiovascular benefits of the GLP-1 receptor agonist, semaglutide (2.4 mg subcutaneous once weekly), in people established atherosclerotic CVD and with a BMI 27 kg/m2 (without type 2 diabetes)
Is retatrutide (LY3437943), a GLP-1, GIP, and glucagon receptor agonist, the next breakthrough for obesity
Daniel Drucker, an endocrinologist at the Lunenfeld-Tanenbaum Research Institute, added that the additional weight loss will be attractive for some, though it will need to be weighed against the side effects
It becomes more functional
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