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A complex interplay of gut hormones called incretins (glucagon-like peptide 1 [GLP-1] and gastric inhibitory polypeptide [GIP]) secreted from K and L cells of the small intestine in response to gastric nutrients, hepatic glucose and insulin, and gastric intrinsic and extrinsic factors as described in following sections bring about the fascinating gluco-gastric equilibrium [56, 57]

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The FDA has never approved ipamorelin for any indication

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