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The formulary is updated frequently and can change from month to month so always check the date to make sure you are reviewing the most recent version of the formulary

Their large peptide structure (Figure 1) makes them prone to enzymatic degradation, lowering bioavailability, and can trigger immunogenicity causing anti-drug antibodies (ADAs)

A Primer for Pharmacists. When CKD or heart failure predominates: For patients with clinically predominant CKD or heart failure, use of an SGLT-2 inhibitor with evidence of reducing heart failure and/or CKD progression are preferably recommended

The chloroacetamide moiety embedded in the chemical structure of RSL3 and ML162 contributes to their GPX4 inhibitory activity [217]

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