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Metabolic syndrome increases the risk of developing cardiovascular diseases and diabetes

Through a targeted chemical screen, the authors identified A11, a small molecule with anti-inflammatory properties, which appears to regulate gene expression putatively by recruiting a repressive complex containing MECP2, HDAC1, SIN3A, and DNMT3A to PU.1 bound regions

Diet-induced metabolic acidosis

Perhaps not surprising, this hindbrain site of action is also responsible for mediating the illness-like behaviors (e.g., nausea, conditioned taste avoidance, emesis) of systemically delivered GLP-1R agonists (43)

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