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The case of GLP-1 illustrates how numerous inventions were needed before we arrived at a medicine that induces double-digit per cent weight loss as well as reduced cardiovascular disease risk in obesity

The protective role of L-carnitine against neurotoxicity evoked by drug of abuse, methamphetamine, could be related to mitochondrial dysfunction

This is particularly meaningful from a research perspective, as elevated triglycerides represent an independent cardiovascular risk factor that is often undertreated by GLP-1 class compounds alone

But the cost of retatrutide remains high, and long-term safety data is limited

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