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79 This route has not been seriously considered as a widely prescribed option for skin lightening treatments

PMID: 34532928

Pigmentation is not common but when it occurs it may be a good idea to consider stopping the medication

The alchemical transformations involved 3 steps: The removal of the softcore atoms partial charges, the transformation of the uncharged softcore atom into the perturbed structure (VdW step), and the reintroduction of the partial charge for the perturbed structure (Fig