Placebo effects, expectation bias, and individual variability all confound interpretation
The Critical Importance of Purity in Research Now, this is where it gets interesting, and it's a point we cannot overstate
If improved health and vitality is what you're after, you should also aim to get plenty of B12 through your food, incorporating health-promoting fortified foods like nutritional yeast, natural fortified cereal, and fortified plant milks into your diet (and maybe a few vegan gummy vitamins on top to help with specific issues)
FOLIC ACID and VITAMIN B12 act in synergy in the formation of DNA , and deficiencies can have serious consequences, both in performance horses with a high tissue turnover rate, and in pregnancy and growth of young foals
doi: 10.1093/jb/mvr134