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Although initially considered a waste product of aerobic glycolysis (e.g., the Warburg effect), lactate has been shown to serve as the primary carbon source for the TCA cycle in vivo, providing substrates, and thus electrons, for oxidative phosphorylation in normal tissue and tumors 2,3

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In late 2024, Zealand Pharma initiated a phase 2b randomized dose-finding obesity and T2DM + obesity clinical trial (ZUPREME-1 and ZUPREME-2) which will evaluate petrelintides efficacy and safety in individuals with obesity in a larger population ( N = 480) [116]

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Prevention of relapse in drug sensitive pulmonary tuberculosis patients with and without vitamin D3 supplementation: a double blinded randomized control clinical trial