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doi: 10.3389/fendo.2025.1684744 Received 13 August 2025 Revised 01 October 2025 Accepted 05 November 2025 Published 21 November 2025 Volume 16 - 2025 Edited by Eleonore Frhlich, Medical University of Graz, Austria Reviewed by Hussam Wahab Al-Humadi, University of Babylon, Iraq Yuting Cui, Affiliated Hospital of Nanjing University of Chinese Medicine, China Updates Copyright 2025 Song, Li, Shi, Liu, Qu and Wang

These complications may be attributed to nutritional deficiencies frequently observed during rapid weight loss, including depletion of iron, vitamin B 12 , fat-soluble vitamins, and proteins

& Reinecker, H

Each additional receptor target adds complexity to the side effect profile, the dose-response relationship, and the long-term safety considerations

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