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Adalimumab has three alternative dosing options: 40mg once weekly 80mg every other week 80mg weekly (off-label use) for patients with severe disease Infliximab dosing: infusion 10mg/kg (high dose) every 4-6 weeks Ustekinumab dosing: 90mg every 4-8 weeks Addressing Inflammation with Steroids Steroid injections at higher concentrations are utilized as a rapid intervention for patients with severe pain or discomfort