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Lipotropic compounds are water-soluble and require adequate plasma volume for hepatic uptake and cellular distribution

It reflects the pharmacological action of the medication working as designed

Wells GA, Shea B, O'Connell D et al: The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomized studies in meta-analyses

Also, due to the important role of endothelial dysfunction in CVD, the effects of GLP-1RA on flow-mediated vasodilation (FMD) in patients remain to be investigated for their contribution to the CVD actions of GLP-1RAs

When combined with insulin or sulfonylureas, dose adjustments of these medications may be necessary to reduce the risk of hypoglycaemia, and should only be made under healthcare professional supervision