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Patients on Proton Pump Inhibitors or Metformin Long-term use of PPIs or metformin has been shown to impair B12 absorption

The smaller studies that make up a meta-analysis can sometimes show larger effects than in a single study that has a lot more participants

More recently, semaglutide (Wegovy) has been recommended by NICE (TA875) as another GLP-1 receptor agonist option for weight management in the UK, administered as a once-weekly injection

[11] It is less preferred than hydroxocobalamin for treating vitamin B 12 deficiency because it has a slightly lower bioavailability

Injections also wont cause stomach upset thats associated with some supplements, and they dont require major changes to your diet, either