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they cause an altered expression of defensin genes, thus facilitating an impaired antimicrobial response to the gut microbiota and promoting the translocation of the bacteria across the epithelium [40]

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0.5 mg/0.1 ml saline/each eye) in rats immediately produced moderate generalized irregularity in the diameter of blood vessels with moderate atrophy of the optic disc and faint presentation of the choroidal blood vessels, and these lesions rapidly progressed to the severe stage