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420 However, KD may contribute to decreased sensitivity to peripheral insulin and impaired glucose tolerance by upregulating insulin receptors, as determined by previous studies, which contradicts clinical findings

31 Thus GLP-1RA may, via GLP-1 receptor signaling in the hypothalamus, interfere with mRNA transcription, translation or the cleavage of ObRb to soluble leptin receptors and thereby down-regulate the production of soluble leptin receptors

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