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A multicenter, randomized, double-blind, multiple dose-escalation study showed that after 4 weeks of treatment of PEX-168 with different doses, the weight decreased by -0.8-1.8kg

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That figure exceeds the Phase 2 result of 24.2% at 48 weeks, which was already among the largest body-weight reductions reported in a randomized obesity trial

There is an alternative methyl-donation process involving Glycine Betaine (GB) in conjunction with the zinc requiring enzyme Betaine-homocysteine S -methyltransferase (BHMT)