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In one aspect, the invention provides methods of preventing or treating muscular weakness in a patient with Parkinson's disease and/or of improving or restoring muscular strength of a patient with Parkinson's disease, by administering one or more hepatocyte growth factor mimics as described herein

These levels remained stable over a 12-month period, suggesting that BDNF is a reliable baseline biomarker when measured consistently

Collaboration across disciplines and cultures is fostering a paradigm where multi-component natural interventions complement single-target drugs

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Limitations of animal research: Rat healing faster than human, young research animals heal better than aged humans, controlled injury models don't replicate complex human injuries perfectly, dosing conversions uncertain (body weight scaling imperfect), immune system differences affect inflammation and healing