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Children with clefts are prone to dental problems like cavities and missing, malformed or displaced teeth
Furthermore, microbiota composition varies depending on its localization in the gastrointestinal system
Given its epidemiology, its diverse presentations, and suboptimal treatment outcomes for some patients, it is becoming evident that a one-size-fits-all approach is inadequate when discussing obesity treatment (69, 70)
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Its downstream signaling through PI3K/Akt/mTOR and MAPK/ERK makes it relevant to a wide range of research questions in muscle biology, bone physiology, neuroprotection, and metabolic signaling
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