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Clinicians need to know when patients experience changes in mood, libido, or motivation on these drugs

Research demonstrates that NNMT expression increases significantly with advancing age, particularly in metabolic tissues, contributing to the progressive decline in NAD+ levels observed during aging

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These explain how DOX causes POI by speeding up the ovarian tissues lipid peroxidation, which makes the antioxidant system incapable of scavenging ROS

Furthermore, behavioral counseling should be integrated to address emotional eating, food cravings, and psychological factors that may hinder adherence