The prevalence of this CYP2D6 phenotype varies widely and has been estimated at 1 to 10% for Whites (European, North American), 3 to 4% for Blacks (African Americans), 1 to 2% for East Asians (Chinese, Japanese, Korean), and may be greater than 10% in certain racial/ethnic groups (i.e., Oceanian, Northern African, Middle Eastern, Ashkenazi Jews, Puerto Rican)
Essentially, your body becomes more energy-efficient
Nucleic Acids Res 45 , D313d319 (2017)
353,354,355 Traditionally, citrate is oxidized in the tricarboxylic acid (TCA) cycle, while high cellular zinc levels in normal prostate cells prevent this process by inhibiting the activity of mitochondrial aconitase (m-aconitase) 356 (Fig
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