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MOTSc is sometimes discussed in preclinical literature in connection with AMPKrelated pathways, which is why AMPK is frequently mentioned alongside MOTSc in metabolismfocused research contexts

In severe cases of obesity, bariatric surgery may be a viable option that can produce profound weight loss and may lead to diabetes and dyslipidemia remission, regardless of the procedure type [23]

The addition of the GIP hormone appears to create a synergistic effect that supports deeper fat loss and better blood sugar regulation

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On the other side, miRNAs interaction with natural compounds, most specifically with curcumin, can also be explored as a new regime for potential theragnostic approaches