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Published January 12, 2016

The ability of metformin to induce weight loss is not directly related to an increase in energy expenditure nor to changes in nutrient absorption but is due to suppression of the desire for food intake

However, the suppression of estradiol observed in whole-NS workers and the loss of estrogen receptor rhythmicity highlight the nuanced and context-dependent nature of endocrine disruption caused by shift work 251

A common approach is to allow the liquid to run down the inside wall of the vial rather than forcing it directly onto the lyophilised material