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This oxidative stress causes widespread damage to cellular components, including lipid peroxidation, protein oxidation, and DNA damage [22]

For gene ontology (GO) analysis, the Seurats FindMarkers output for the specified groups was used to plot gene ontology terms with the barcodeplot functions from limma 131

The most dramatic increase is in the perimenopause population: as of February 2026, 1 in 20 women aged 4554 has an active estrogen-based HRT prescription, a 184% increase across the study period

Patients with HT who received replacement with levothyroxine (L-T4) did not always achieve clinically significant results, which requires additional therapeutic agents (17)

But thats not all, it also helps repair DNA