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Horton JD, Shimano H, Hamilton RL, Brown MS, Goldstein JL (1999) Disruption of LDL receptor gene in transgenic SREBP-1a mice unmasks hyperlipidemia resulting from production of lipid-rich VLDL

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The peptides very short half-life (3 minutes) means it does not accumulate in tissues over time, reducing concerns about long-term bioaccumulation

These consisted of five clinical trials, four real-world observational studies and the completed trial (SURPASS-CVOT) was included separately to serve as a contextual cardiovascular outcomes study

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