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GHRH receptor activation and GHS-R1a activation engage distinct intracellular signaling cascades cAMP/PKA and IP3/calcium mobilization pathways respectively that converge at the level of GH vesicle exocytosis to produce a synergistically amplified secretory response

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C18 Side Chain: Lysine at position 26 is acylated with an 18-carbon fatty diacid and a 2xOEG spacer, allowing for tighter binding to plasma albumin and reduced renal ltration

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