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Within these mechanisms, the PHPMA backbone undergoes modification with biodegradable oligopeptide side chains, with targeting antibodies and medications attached to the ends, distributed sporadically along the backbone

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These two pathways cooperate in several ways: IFN-I generated by cGAS-STING heightens NLRP3 sensitivity, and NLRP3-dependent IL-1 upregulates cGAS via NF-KB, creating a positive-feedback loop

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