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Yes, semaglutide can cause heart palpitations and an increased pulse

Ryan, MD, Professor Emerita, Pennington Biomedical Research Center

The high concentration of leptin in the circulation of obese patients causes the desensitization of leptin receptors in the hypothalamus and then a secondary reduction in the secretion of GnRH and gonadotropins

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These include exenatide (exendin-4), which enhances insulin production and has 53% sequence identity to GLP-1 but has a half life of only 2.4 hours and must be taken twice a day with other anti-diabetic drugs, typically metformin or sulfonylurea