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It is estimated that currently about 415 million individuals are diagnosed with DM worldwide and it is predicted that by 2040 these records will reach the range of 672 million [2]

In line with decreased expression of key enzymes involving -oxidation (Figure 3, A and B), metabolomic analysis demonstrated significantly decreased levels of multiple acyl-carnitine species, without alterations in free carnitine levels (Figure 4, EG)